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2-Bromo-3',4'-(methylenedioxy)propiophenone ( 52190-28-0 )
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  • 2-Bromo-3',4'-(methylenedioxy)propiophenone ( 52190-28-0 )
  • 2-Bromo-3',4'-(methylenedioxy)propiophenone ( 52190-28-0 )

2-Bromo-3',4'-(methylenedioxy)propiophenone ( 52190-28-0 )

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Product Name: 2-Bromo-3',4'-(methylenedioxy)propiophenone
Synonyms: 1-(benzo[d][1,3]dioxol-5-yl)-2-bromopropan-1-one;2-Bromo-3',4'-(methylenedioxy)propiophenone;1-(1,3-Benzodioxol-5-yl)-2-broMo-1-propanone;3',4'-Methylenedioxy-α-broMopropiophenone;1-(1,3-benzodioxol-5-yl)-2-bromopropan-1-one;1-Propanone, 1-(1,3-benzodioxol-5-yl)-2-bromo-;3',4'-Methylenedioxy-α-broMopropiophenone;Bromo-3′ , 4′ - (methylenedioxy)
CAS: 52190-28-0
MF: C10H9BrO3
MW: 257.08
EINECS: 207-791-3
Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 52190-28-0.mol
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2-Bromo-3',4'-(methylenedioxy)propiophenone

CAS No.
52190-28-0
Chemical Name:
2-Bromo-3',4'-(methylenedioxy)propiophenone
Synonyms
Bromo-3′ , 4′ - (methylenedioxy);3',4'-Methylenedioxy-α-broMopropiophenone;3',4'-Methylenedioxy-α-broMopropiophenone;2-Bromo-3',4'-(methylenedioxy)propiophenone;2-Bromo-3',4'-(methylenedioxy)propiophenone;1-(1,3-benzodioxol-5-yl)-2-bromopropan-1-one;1-(1,3-Benzodioxol-5-yl)-2-broMo-1-propanone;1-Propanone, 1-(1,3-benzodioxol-5-yl)-2-bromo-;1-(benzo[d][1,3]dioxol-5-yl)-2-bromopropan-1-one;Name 2-Bromo-3',4'-(methylenedioxy)propiophenone
CBNumber:
CB6966513
Molecular Formula:
C10H9BrO3
Molecular Weight:
257.08

MDL Number:
MFCD12403547

MOL File:
52190-28-0.mol

2-Bromo-3',4'-(methylenedioxy)propiophenone Properties

Boiling point 345.7±42.0 °C(Predicted)
Density 1.584±0.06 g/cm3(Predicted)
solubility

Chloroform: Soluble; DMSO:

1 mg/mL*; Ethanol: 1 mg/mL
form A crystalline solid
InChI

InChI=1S/C10H9BrO3/c1-6(11)10(12)

7-2-3-8-9(4-7)14-5-13-8/h2-4,6H,5H2,1H3
InChIKey NTPQGLLTGPTOAA-UHFFFAOYSA-N
SMILES C(C1=CC=C2OCOC2=C1)(=O)C(Br)C

2-Bromo-3',4'-(methylenedioxy)propiophenone Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Uses

1-(benzo[d][1,3]dioxol-5-yl)-2-bromopropan-1-one (2-Bromo-3',4'-(methylenedioxy)propiophenone) can be used in the preparation of antifungal agents and MDMA analogs.

Application

2-Bromo-3',4'-(methylenedioxy)propiophenone, also known as 4′-(methylenedioxy)propiophenone, is an analytical reference standard categorized as a precursor in the synthesis of cathinones. This product is intended for research and forensic applications.

Synthesis

Bromine (10.0 mmol) was added to a solution of the ketone (10.0 mmol) in Et2O (25 mL). The solution was stirred for 30 min (until the color of the solution changed from red to light-yellow). Then, the reaction was quenched with water (10 mL), and the mixture was diluted with Et2O (25 mL). The organic layer was washed with a saturated solution of aqueous NaHCO3 (30 mL), a saturated solution of aqueous Na2S2O3 (30 mL), and brine (30 mL), and then it was dried over MgSO4, filtered, and concentrated. The α-bromoketone was purified by flash chromatography on silica gel. 2-Bromo-3',4'-(methylenedioxy)propiophenone [52190-28-0]. This compound was prepared according to the General Procedure from 3,4-methylenedioxypropiophenone (1.78 g, 10.0 mmol). The product was obtained as a white solid (eluted with 50% CH2Cl2 in hexanes; 2.13 g, 82% yield). 1H NMR (CDCl3, 500 MHz) δ 7.64 (d, J= 8.0 Hz, 1H), 7.49 (s,

2-Bromo-3',4'-(methylenedioxy)propiophenone Preparation Products And Raw materials

Alternate Names:
1-(1,3-Benzodioxol-5-yl)-2-bromo-1-propanone; 3′,4′-Methylenedioxy-?-bromopropiophenone
CAS Number:
52190-28-0
Molecular Weight:
257.08
Molecular Formula:
C10H9BrO3
2-Bromo-3',4'-(methylenedioxy)propiophenone Usage And Synthesis
Chemical Properties Pale Yellow Solid
Uses 1-(benzo[d][1,3]dioxol-5-yl)-2-bromopropan-1-one (2-Bromo-3',4'-(methylenedioxy)propiophenone) can be used in the preparation of antifungal agents and MDMA analogs.
Application 2-Bromo-3',4'-(methylenedioxy)propiophenone, also known as 4′-(methylenedioxy)propiophenone, is an analytical reference standard categorized as a precursor in the synthesis of cathinones. This product is intended for research and forensic applications.
Synthesis Bromine (10.0 mmol) was added to a solution of the ketone (10.0 mmol) in Et2O (25 mL). The solution was stirred for 30 min (until the color of the solution changed from red to light-yellow). Then, the reaction was quenched with water (10 mL), and the mixture was diluted with Et2O (25 mL). The organic layer was washed with a saturated solution of aqueous NaHCO3 (30 mL), a saturated solution of aqueous Na2S2O3 (30 mL), and brine (30 mL), and then it was dried over MgSO4, filtered, and concentrated. The α-bromoketone was purified by flash chromatography on silica gel. 2-Bromo-3',4'-(methylenedioxy)propiophenone [52190-28-0]. This compound was prepared according to the General Procedure from 3,4-methylenedioxypropiophenone (1.78 g, 10.0 mmol). The product was obtained as a white solid (eluted with 50% CH2Cl2 in hexanes; 2.13 g, 82% yield). 1H NMR (CDCl3, 500 MHz) δ 7.64 (d, J= 8.0 Hz, 1H), 7.49 (s, 1H), 6.87 (d, J= 8.0 Hz, 1H), 6.07 (s, 2H), 5.21 (q, J= 7.0 Hz, 1H), 1.88 (d, J= 7.0 Hz, 3H).

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