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  • Buy Muscimol (CAS 2763-96-4)
  • Buy Muscimol (CAS 2763-96-4)

Buy Muscimol (CAS 2763-96-4)

$4,700.00
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Alternate Names:
3-Hydroxy-5-aminomethyl-isoxazole;5-Aminomethyl-3-isoxazolol;5-Aminomethyl-3-hydroxy-isoxazole
Application:
Muscimol is a potent and specific GABAA receptor agonist/GABA analog
CAS Number:
2763-96-4
Purity:
≥98%
Molecular Weight:
114.10
Molecular Formula:
C4H6N2O2
Quantity

Alternate Names:
3-Hydroxy-5-aminomethyl-isoxazole;5-Aminomethyl-3-isoxazolol;5-Aminomethyl-3-hydroxy-isoxazole
Application:
Muscimol is a potent and specific GABAA receptor agonist/GABA analog
CAS Number:
2763-96-4
Purity:
≥98%
Molecular Weight:
114.10
Molecular Formula:
C4H6N2O2
Muscimol is a naturally occurring alkaloid that can be found in Amanita mushrooms. It is functional as a potent and selective agonist of the GABAA receptor. The structure of Muscimol places the binding functionalities (amine, hydroxyl) in a spatial arrangement almost identical to that of GABA, allowing recognition of Muscimol at the highly specific GABAA binding site. Muscimol has been widely employed for this agonist activity in studies probing the consequent effects of GABAA stimulation.
Application Notes
 
Muscimol has been widely used to reversibly inactivate localized groups of neurons. It can also be used, in place of radioactive reagents and methods, to map the distribution of muscimol in the nervous system, as well as to detect the presence of GABAA receptors on cell surfaces. Muscimol was also reported to cause change in the water intake of the mice. In cultured rat oligodendrocytes, muscimol has been shown to lead to a reduction in intracellular Cl-content, cell shrinkage, and stimulated Na-K-2Cl cotransporter isoform 1 (NKCC1) activity. Muscimol (50 mM) has been utilized to probe the role of the p42/44 mitogenactivated protein kinase (MAPK) cascade in the development of cultured rat hypothalamic neurons.
 
Usage Statement
 
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
 
Key Applications
 
GABA-agonist
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