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Synonyms:AM-2201 (AM 2201;[1-(5-fluoropentyl)-1H-indole-3-yl](naphthalene-1-yl)methanone;AM-2201 (1-[(5-fluoropentyl)-1H-indol-3-yl]-(naphthalen-1-yl)methanone);1-(5-Fluoropentyl)-3-(1-naphthoyl)-1H-indole;1-(5-fluoropentyl)-3-[(naphthalen-1-yl)carbonyl]-1H-indole;(1-(5-Fluoropentyl)-3-(naphthalen-1-oyl)indole);(1-(5-fluoropentyl)-1H-indol-3-yl)(naphthalen-1-yl)Methanone;1-(5-fluoropentyl)-3-(naphtalen-1-oy)indole
AM2201 is a potent synthetic cannabinoid (CB) with Ki values of 1.0 and 2.6 nM for the CB1 and CB2 receptors, respectively. The physiological actions and metabolism of AM2201 have not been characterized.
This product is a qualified Reference Material (RM) that has been manufactured and tested to meet ISO17025 and Guide 34 guidelines. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability of measurements. All traceable RMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support.
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what’s AM-2201 / AM2201. | Order AM-2201 online
buy AM-2201 online/AM2201 . AM-2201 is an aminoalkylindole used as an energetic factor of merchandise offered as hashish substitutes. When smoked, AM-2201 produces cannabimimetic results in doses decreased than the doses of Δ9-tetrahydrocannabinol (THC) had to produce results of comparable strength (better potency).
Many of the dangers connected to hashish use also are gifts withinside the case of AM-2201, amongst them headaches in sufferers tormented by cardiovascular illnesses and triggering of acute psychosis. Abuse ability and dependence ability appear to be much like hashish. One of the primary variations between hashish and this artificial cannabinoid is the extra acute toxicity of AM-2201. buy AM-2201 online/AM2201
Due to its complete agonistic movement on the CB1 receptor and enormously excessive potency, the aspect results of better doses may be life-threatening. This is annoying with the aid of using the reality that dosing could be very hard because of converting contents of energetic elements in unique merchandise, unique batches of the equal product, or even inside one packet. Regarding continual toxicity, dangers are very hard to estimate on the idea of the to-be-had data. Buy AM-2201 Powder Online
However, there are issues approximately the ability carcinogenic results. In comparison to JWH-018 and JWH-073, AM-2201 consists of a fluorine atom on the five roles of the alkyl aspect chain, which is challenging to metabolic transformation and offers an upward push to extra challenge in regards to ability toxicity . buy AM-2201 online/AM2201.
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AM2201 (Item No. 10707) is an analytical reference fabric characterized as an artificial cannabinoid. AM2201 is regulated as a Schedule I compound withinside the United States. This product is supposed for studies and forensic applications.
Substance identification — buy AM-2201 online/AM2201
-International Nonproprietary Name (INN) : Not applicable
-Chemical Abstract Service (CAS) Registry Number: 335161-24-5
-Other Names : AM-2201, AM2201, 1-(5-fluorophenyl)-3-(1-naphthoyl)indole, JWH 2201
Street Names : ‘Spice’, ‘K2’, ‘felony weed’, ‘artificial cannabis’, ‘natural incense’
AM-2201 become located as an additive in over ninety specific manufacturers of ‘natural combinations’ in Germany alone (personal unpublished information). This merchandise had been sporting fable names like e.g.: ‘Agent Orange’, ‘Atomic Bomb’, ‘Green’, ‘Jamaican Gold Extreme’, ‘Manga Xtreme’, ‘New Bonzai’, and ‘XoXo’.
One must be aware of the truth that combinations offered beneath unique emblem names do now no longer constantly comprise the equal substance or aggregate of materials over time.
– Physical properties: White crystalline solid (in natural form), soluble at ~5mg/ml in ethanol.
– WHO Review History on buy AM-2201 online/AM2201
AM-2201 become now no longer formerly pre-reviewed or significantly reviewed. A direct essential overview is being proposed primarily based totally on statistics introduced to WHO’s interest that AM-2201 is clandestinely manufactured, of in particular severe chance to public fitness and society, and of no identified healing use with the aid of using any party.
Preliminary information amassed from literature and specific international locations indicated that this substance can also additionally purpose massive damage and that it has no clinical use. buy AM-2201 online/AM2201
Chemical Structure of AM-2201/AM2201 — Purchase AM-2201
Molecular Formula: C24 H 22 FNO
Molecular Weight: 359.43 g/mol
Melting point: 93.7 °C
Boiling point: n/a
Fusion point: n/a
Synthesis of AM-2201/AM2201 — AM-2201 for sale
Synthesis of AM-2201 changed into first suggested in 2001 with the aid of using Alexandros Makriyannis and Hongfeng Deng. Starting from a 1-H indole answer in acetic acid ethyl ester, an answer of methyl magnesium bromide in acetic acid ethyl ester is introduced. buy AM-2201 online/AM2201
Then, naphthalene-1-carbonyl chloride (organized from naphthalene-1-carboxylic acid and thionyl chloride) is introduced, accompanied with the aid of using the addition of an aqueous answer of ammonium chloride. Afterward, the received filtrate of 1H-indol-three- yl(naphthalen-1-yl)methanone is washed and recrystallized. buy AM-2201 online/AM2201
This product is introduced to a suspension of sodium hydride in dimethylformamide (DMF) accompanied with the aid of using the addition of five bromopentylacetate for N-alkylation. After cleavage of the acetate, the use of a methanolic potassium hydroxide answer, fluorination of the pentyl facet chain is done using diethylaminosulfur trifluoride (DAST) and dichloromethane .
Commercially to be had a home or commercial merchandise, which can be used for synthesis, may also include different doubtlessly poisonous materials, which include heavy metals and natural solvents. The use of such merchandise as reagents may also bring about critical poisonous outcomes if the ensuing impure product is consumed. buy AM-2201 online/AM2201
The natural cloth that is used as a foundation for the smoking combos may also include toxicologically applicable materials like e.g. pesticides, too. buy AM-2201 online/AM2201
Chemical description of AM-2201/AM2201 —
AM-2201 is a naphthoylindole alkylated on the indole nitrogen and includes a fluorine atom on the five-function of the pentyl facet chain.
Chemical residences of AM-2201/AM2201 —
Chemically, AM-2201 may be appeared as notably inert as its miles substituted on the reactive C-three function with the naphthyl moiety. Due to the aromaticity of the indole device the nitrogen does now no longer result in great basicity. In comparison to non-fluorinated analogs, at better temperatures AM-2201 can be transformed into JWH-018 and JWH-022 to a minor extent . buy AM-2201 online/AM2201
AM-2201/AM2201 Chemical identification —
The analytical profile of AM-2201 has been defined in numerous papers. Utilized techniques encompass LC-MS/MS , GC-EI-MS , LC-Q-ToF-MS , AccuTOF-DART , NMR , FTIR ATR, and UV-VIS detection. Detection in organic matrices turned into defined in serum, complete blood, hair and oral fluid concentrated on AM-2201. In urine samples, the primary metabolites are the analytical targets. buy AM-2201 online/AM2201
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When heated (e.g. throughout smoking), AM-2201 can be transformed into JWH-018 to a minor extent, which turned into one of the first artificial cannabinoids to be covered in numerous country-wide narcotics laws. However, AM-2201 isn’t taken into consideration as an instantaneous precursor of any world-over-managed substance. buy AM-2201 online/AM2201
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Pharmacodynamics of AM-2201/AM2201
In vivo information on pharmacodynamics of AM-2201 has now no longer been posted so far. However, AM-2201 possesses a fantastically excessive binding affinity (expressed as IC50 (profession of 50% of the receptors)) closer to the cannabinoid receptor kind 1 (CB1) of 1. zero nM and closer to the cannabinoid receptor kind 2 (CB2) of 2.6 nM in comparison tothe binding affinities of delta-nine tetrahydrocannabinol (THC) of 40.7 ± 1.7 nM on the CB1 and 36.4 ± 10 nM on the CB2 receptor. buy AM-2201 online/AM2201
Furthermore, Nakajima et al. and Chimalakonda et al. examined the organic outcomes with the aid of using making use of an in vitro guanosine-5’-O-(3-thio)-triphosphate (GTPγS) binding assay, measuring a 50 fictive concentration (EC50) of zero.24 nMand complete agonistic properties.
Based in this information and medical observations, it may be assumed that AM-2201 suggests standard outcomes of CB1 agonists. These outcomes can encompass sedation, cognitive dysfunction, tachycardia, postural hypotension, dry mouth, ataxia, immunosuppression and psychotropic outcomes. buy AM-2201 online/AM2201
A reported distinction with reference to THC is the formation of doubtlessly pharmacologically energetic AM-2201 metabolites. While withinside the case of THC, handiest one of the predominant THC-metabolites is understood to be psychoactive and keeps binding affinity closer to cannabinoid receptors (11-OH-THC: Ki at CB1 receptor: 38.4 ± zero. eight nM), numerous AM-2201 metabolites preserve excessive CB1 receptor binding affinity (relative rank of binding affinities: AM-2201 > AM-2201 N-(4-OH-pentyl) = JWH-018 N-(5-OH- pentyl) > THC > JWH-073 N-(4-OH-butyl)) .
Furthermore, comparable efficacy for AM-2201 (a complete agonist) and the 2 AM-2201 metabolites AM-2201 N-(4-OH- pentyl) and JWH-018 N-(5-OH-pentyl) has been proven and partial agonistic pastime for JWH-073 N-(4-OH-butyl. The glucuronidated JWH-018 N-(5-OH-pentyl) metabolite keeps binding affinity closer to the CB1 receptor and pastime as an impartial antagonist (Ki: 922 nM). buy AM-2201 online/AM2201
No information is to be had regarding the query whether or not this metabolite of JWH-018 is able to antagonize pharmacological outcomes of JWH-018 in vivo, and if enough concentrations are shaped on the web website online of action. buy AM-2201 online/AM2201
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